Error Code:49

Juno on my desktop will not open. I get a message saying it has detected a technical problme with my mailbox, and later that it was able to repair it. When I click OK I get an "uspecified error" message. When I click OK I get "Initial user failed" When I click on OK I get an Offline email filed to initialize box with "Error Code 49" When I click OK Email client closes. I went to: Start > All Programs > Accessories > System Tools > System Restore, then restored my system back to a date and time when I was able to open my email. I continue to get the same message and Juno shuts down.